| Acronym | Definition |
|---|
| RLE | Run Length Encoding |
| RLE | Red List of Ecosystems (International Union for Conservation of Nature) |
| RLE | Right to Left Embedding |
| RLE | Right-to-Left Embedding |
| RLE | Related Learning Experience (various organizations) |
| RLE | Réseau Local d'Entreprise (French: Local Area Network) |
| RLE | Required Local Effort |
| RLE | Rouelle (French: Lane; Canada Post street designation) |
| RLE | Remaining Life Expectancy |
| RLE | Roast-Leach-Electrowin (zinc smelting) |
| RLE | Rat Liver Epithelial Cell |
| RLE | Right Lower Extremities |
| RLE | Robert Lee Entertainment (California) |
| RLE | Rhône-Alpes Location Equipement (French rental equipment company) |
| RLE | Recursive Least Entropy |
| RLE | Repair and Life Extension (ship repair) |