| Acronym | Definition |
|---|
| SMILE | Security Made in Lëtzebuerg (cyber-crime group, Luxembourg) |
| SMILE | Social Media the Internet and Law Enforcement (conference) |
| SMILE | Seamonkey Interface Library for Extensions |
| SMILE | Sparc Macrocell and Interface Library Elements |
| SMILE | Structure, Meaning, Imagery, Language, Effect (literature education) |
| SMILE | Science and Math Investigative Learning Experiences Program |
| SMILE | Spatial Multiplexing of Local Elements |
| SMILE | Smart-Power ICs (Integrated Circuits) for Lighting Applications |
| SMILE | Spiritually Minded Is Life Eternal |
| SMILE | Students Making It a Little Easier (freshman orientation in West Caldwell NJ) |
| SMILE | Students' Mobilization Initiative for Learning Through Exposure (Indian youth initiative) |
| SMILE | Stanford Medicine Information and Learning Environment |
| SMILE | Students Mastering Important Lifeskills Education |
| SMILE | Single Mothers in A Learning Environment |
| SMILE | Service Makes Individual Lives Exciting |
| SMILE | Smart Management Interface Local Exchange |
| SMILE | Spreading Multiculturalism and Inspiring Leadership Through Education (Berkeley, CA) |
| SMILE | Signal, Mirror, Interior, Lights, Engine (drivers education) |
| SMILE | Semiconductor Microcavity Light Emitter |
| SMILE | Self Motivation In Lasting Endorphins (UK self-help group) |
| SMILE | Saving More Illinois Lives Through Education (health project) |