| Acronym | Definition |
|---|
| SHU | Seton Hall University (South Orange, New Jersey, USA; founded in 1856) |
| SHU | Sheffield Hallam University (UK) |
| SHU | Sacred Heart University (Fairfield, CT, USA) |
| SHU | Shanghai University |
| SHU | Siena Heights University (Adrian, MI) |
| SHU | Syndrome Hémolytique et Urémique (French: Hemolytic Uremic Syndrome) |
| SHU | Seton Hill University (Greensburg, Pennsylvania) |
| SHU | Shared User |
| SHU | Special Housing Unit (prison) |
| SHU | Security Housing Unit (prison) |
| SHU | School Health Unit (various schools) |
| SHU | Scoville Heat Unit |
| SHU | Segregated Housing Unit (prison) |
| SHU | Selective Hydrogenation Unit |
| SHU | Solitary Housing Unit |
| SHU | Ships Head Up (type of marine radar display) |
| SHU | Split-Horison Updates |