| Acronym | Definition |
|---|
| SAFER | Students Active For Ending Rape |
| SAFER | Staffing for Adequate Fire and Emergency Response (US Department of Homeland Security) |
| SAFER | Secure and Fast Encryption Routine |
| SAFER | Steel And Foam Energy Reduction (racetrack barrier developed by University of Nebraska) |
| SAFER | Simplified Aid For EVA Rescue |
| SAFER | Société d'Aménagement Foncier et d'Etablissement Rural (French: Property and Rural Settlement Development Corporation) |
| SAFER | Safer Alternatives for Enjoyable Recreation (pro-marijuana group) |
| SAFER | Secure and Fast Encryption Routine (cryptography) |
| SAFER | Safety Assessment for Evaluating Rehoming |
| SAFER | Evasion and Recovery Selected Area for Evasion (SAFE) Area Activation Request (US DoD) |
| SAFER | Streamlined Approach for Environmental Restoration (US DoE) |
| SAFER | Southern Area Fire Equipment Research |
| SAFER | Split Access Flexible Egress Routing (AT&T) |
| SAFER | Safety and Fitness Electronics Records System (Johns Hopkins University) |
| SAFER | Sandwell Approach Forum for Eliminating Racism (UK) |