| Acronym | Definition |
|---|
| HPO | High Performance Organization |
| HPO | Hospital Police Officer (California) |
| HPO | Hyperparameter Optimization (machine learning) |
| HPO | High Profile Object |
| HPO | Hamilton Philharmonic Orchestra (Ontario, Canada) |
| HPO | Hungarian Patent Office |
| HPO | Head Post Office |
| HPO | High Performance Option |
| HPO | Homeowner Protection Office (Canada) |
| HPO | Hypothalamic-Pituitary-Ovary (biology) |
| HPO | Highway Post Office |
| HPO | High Priority Occupation (Pennsylvania) |
| HPO | Health Promotion Officer |
| HPO | High Purity Oxygen |
| HPO | Hurricane Protection Office (USACE) |
| HPO | Home Port |
| HPO | Heavy Pyrolysis Oil (Chevron Phillips Chemical) |
| HPO | High Power Objective (microscope lens) |
| HPO | Hosted Payload Opportunities (Geostationary Earth Orbit; US NASA) |
| HPO | Horizontal Parallax Only (electronic holography) |
| HPO | Hitachi Philharmonic Orchestra (est. 1995; Japan) |
| HPO | Helix-Profile Optimization |
| HPO | Human Phenotype Ontology |
| HPO | Hoechst Aktiengesellschaft & Co. Procurement Olefin KG |
| HPO | Hypertrophic Pulmonary Osteopathy (pathology) |
| HPO | Hourly Postflight Inspection |
| HPO | Honours Pathway Option (Australia) |
| HPO | High Power Operation |
| HPO | Human Powered Ornithopter Project (University of Toronto; Canada) |
| HPO | Houston Premium Outlets |