| Acronym | Definition |
|---|
| GDE | Guide |
| GDE | Google Desktop for Enterprise |
| GDE | Generic Decryption Engine |
| GDE | Global Desktop Environment |
| GDE | Google Developer Experts |
| GDE | Gross Depositional Environment (energy exploration) |
| GDE | Gesamtbetrag der Einkünfte (German: Total Income; taxes) |
| GDE | Gewerkschaft Der Eisenbahner (German) |
| GDE | Graduate Diploma in Education (various schools) |
| GDE | Global Data Excellence (est. 2007) |
| GDE | General Dynamics Electronics Division |
| GDE | Graphical Development Environment |
| GDE | Goal-Directed Echocardiography |
| GDE | Groundwater Dependent Ecosystem (environmental science) |
| GDE | Geospatial Data Exploitation |
| GDE | Ghosts Don't Exist (film) |
| GDE | Generic Data Exemption |
| GDE | Geometric De-Eutrophication (software reliability model) |
| GDE | Graham Dewitt Enterprises (Australia) |
| GDE | Gimbal Drive Electronics |
| GDE | GNOME (GNU (Gnu's Not Unix) Network Object Model Environment) Desktop Environment |
| GDE | Groupe Démocrate Européen (French) |
| GDE | Gibbs Duhem Equation |
| GDE | Group Insurance Data Entry |
| GDE | Grooming Drop Edge |
| GDE | Geo-Technical Drilling & Exploration |
| GDE | Game Design Expo |
| GDE | Gross Domestic Expense |
| GDE | Google Does Exist (internet slang) |